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Scientist > Dr. Anne Mahringer

Dr. Anne Mahringer

studied pharmacy at Heidelberg University, receiving her doctorate in 2009 from the Institute of Pharmacy and Molecular Biotechnology. In the course of several overseas positions in the US (NIEHS, MDIBL) and Sweden (University of Uppsala), she acquired specialised knowledge of both ex vivo and in vivo barrier models and methods for determining pharmacokinetic parameters, with the objective of predicting the blood-brain barrier permeability of drug substances. As a research fellow at the Institute of Pharmacy and Molecular Biotechnology, Anne Mahringer is involved in both teaching and research in the field of ABC transporter regulation mechanisms at the blood-brain barrier and kidneys, and is investigating the endocytotic transport processes of larger peptide molecules in the vascular endothelium in connection with Parkinson's.

Contact: laborundmore@succidia.de

Complex API delivery

Cellular transport proteins and API transport - von Prof. Gert Fricker, Dr. Anne Mahringer

A medicine's potency often depends on the concentration of its active ingredient (API) at the target site. Medicines are usually delivered remotely to this target site, however. The API must first dissolve and traverse local barriers such as the intestinal wall before it can enter the bloodstream and then reach its target site. For a long time, work in this area was guided by the dogma that API diffusion was the force driving absorption by the body...