Pharmaceutical counterion determinationHouse lights down, stage lights up - von Dr Frank Steiner, Dr Carsten Paul, Dr Mark Tracy
In contemporary practice, roughly half of all active pharmaceutical ingredients (APIs) are administered as salts. The use of the protonated or deprotonated form of the drug substance combined with the selection of counterions enables the targeted variation of key parameters, such as solubility and stability. Analysis of the corresponding counterions constitutes an essential part of the development process for new pharmaceuticals and is now an...
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