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L&Mint-int-1-2014

A new application for microscopy

Non-invasive cancer diagnosis - von Dr Leo Habets

Cancer has been a part of human life from our earliest days. In research conducted by Aachen-based oncologist Dr Leo Habets, a non-invasive, microscope-based diagnostic procedure has the potential to revolutionise research and progress in understanding the circumstances of the disease, so as to ­develop new therapeutic approaches. Microscope-based high-content screening systems in basic clinical research: can a non-­invasive procedure replace the...

Biofortification of vegetables with micronutrients

An extra portion of zinc - von Prof. Dr Stephan Clemens

Powerful forearms, a pipe in the mouth, a sailor's hat: It takes him only seconds to open and empty the can of spinach. He faces his next brawl with superhuman strength. This is how we all know Popeye, the sailor. The secret of his strength is in the high iron content of spinach. This idea got innumerable parents to trying to get their children to “like” the ­rather unpopular vegetable. Unfortunately, some things are quite wrong here: While spinach...

Clenbuterol testing in doping control samples: drug abuse or food contamination?

Meat as a doping trap - von Prof. Dr Mario Thevis, Prof. Dr Wilhelm Schänzer

Clenbuterol, a ß<sup>...

Nano Crystals for mega Fluorescence Amplification

SuperNova in the test tube - von Prof Dr Reinhard Renneberg, Jan Engels, Dr Hans-Georg Eisenwiener

We tell the exciting story of how mega ­fluorescence amplification was ­invented. ­
First, there was the question: How can ­previous biochemical evidence reactions ­be ­amplified million-fold to detect the bio­­chemical “needles in a haystack” (substances ­at very low concentrations) in a multicomponent system like a blood sample?

Non-target screening, suspected-target screening and target screening – of technologies and philosophies, databases and crafts

Detective work with molecular accuracy - von PD Dr Thomas Letzel

The three terms in the title, as well as “Known Unknowns” and “Unknown Unknowns” are new keywords that are currently con­fusing the analytical water scene. The procedure in use of just these ­technologies, however, often is not consistent yet. This article will now try to put the many different terms and approaches into some ­semblance of order. At the same time, it will report on pragmatic appli­cations.

Pharmaceutical counterion determination

House lights down, stage lights up - von Dr Frank Steiner, Dr Carsten Paul, Dr Mark Tracy

In contemporary practice, roughly half of all active pharmaceutical ­ingredients (APIs) are administered as salts. The use of the protonated ­or deprotonated form of the drug substance combined with the selection of counterions enables the targeted variation of key parameters, such as solubility and stability. Analysis of the corresponding counterions constitutes an essential part of the development process for new pharmaceuticals and is now an...

L&M int. 1 / 2014

The articles are publishes in issue L&M int. 1 / 2014. Free download here: download here